Alfried Krupp Promotional Prize for Lucas T. Jae

The biochemist was awarded the renowned Alfried Krupp Prize for his research on the genetic and molecular basis of mitochondrial function.
Lucas T. Jae uses a unique screening system to study the role of mitochondria in human disease processes. Mitochondria are cell organelles that are considered the "power plants of the cell". Since they play a key role in metabolism, defects in them lead to severe, mostly incurable diseases in humans, such as a number of hereditary metabolic disorders and myopathies as well as age-related diseases in the areas of neurodegeneration and cardiovascular diseases. Mitochondrial stress processes are easy to depict in models, but are largely not understood in humans.